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Index > Protein center > MST1(Gene name) > Human
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  • MST1 (Gene name),
  • Hepatocyte growth factor-like protein (Protein name ),  HGFL_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MST1(D3F15S2;DNF15S2;HGFL);
    Protein name:
    Hepatocyte growth factor-like protein;
    Alternative:
    Macrophage-stimulating protein(MSP);Macrophage stimulatory protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Dimer of an alpha chain and a beta chain linked by a disulfide bond.
    Function:
    Probably has no proteolytic activity, since crucial characteristic of serine proteases catalytic sites are not conserved.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    711
    Sequence:
    50:
    MGWLPLLLLL | TQCLGVPGQR | SPLNDFQVLR | GTELQHLLHA | VVPGPWQEDV | 
    100:
    ADAEECAGRC | GPLMDCRAFH | YNVSSHGCQL | LPWTQHSPHT | RLRRSGRCDL | 
    150:
    FQKKDYVRTC | IMNNGVGYRG | TMATTVGGLP | CQAWSHKFPN | DHKYTPTLRN | 
    200:
    GLEENFCRNP | DGDPGGPWCY | TTDPAVRFQS | CGIKSCREAA | CVWCNGEEYR | 
    250:
    GAVDRTESGR | ECQRWDLQHP | HQHPFEPGKF | LDQGLDDNYC | RNPDGSERPW | 
    300:
    CYTTDPQIER | EFCDLPRCGS | EAQPRQEATT | VSCFRGKGEG | YRGTANTTTA | 
    350:
    GVPCQRWDAQ | IPHQHRFTPE | KYACKDLREN | FCRNPDGSEA | PWCFTLRPGM | 
    400:
    RAAFCYQIRR | CTDDVRPQDC | YHGAGEQYRG | TVSKTRKGVQ | CQRWSAETPH | 
    450:
    KPQFTFTSEP | HAQLEENFCR | NPDGDSHGPW | CYTMDPRTPF | DYCALRRCAD | 
    500:
    DQPPSILDPP | DQVQFEKCGK | RVDRLDQRRS | KLRVVGGHPG | NSPWTVSLRN | 
    550:
    RQGQHFCGGS | LVKEQWILTA | RQCFSSCHMP | LTGYEVWLGT | LFQNPQHGEP | 
    600:
    SLQRVPVAKM | VCGPSGSQLV | LLKLERSVTL | NQRVALICLP | PEWYVVPPGT | 
    650:
    KCEIAGWGET | KGTGNDTVLN | VALLNVISNQ | ECNIKHRGRV | RESEMCTEGL | 
    700:
    LAPVGACEGD | YGGPLACFTH | NCWVLEGIII | PNRVCARSRW | PAVFTRVSVF | 
    711:
    VDWIHKVMRL | G
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    UniGene:
    String:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Hepatocyte growth factor-like protein
    Cat.:
    E1121m
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    MSDS:
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    96T
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    ELISA Kit for Human Hepatocyte growth factor-like protein
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    E1121h
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    MSDS:
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    96T
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    ELISA Kit for Human Hepatocyte growth factor-like protein
    Cat.:
    E1121b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Hepatocyte growth factor-like protein
    Cat.:
    U1121h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Hepatocyte growth factor-like protein
    Cat.:
    U1121m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Hepatocyte growth factor-like protein
    Cat.:
    U1121b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Hepatocyte growth factor-like protein
    Polyclonal Antibody for Human Hepatocyte growth factor-like protein
    Cat.:
    P1121Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Hepatocyte growth factor-like protein
    Cat.:
    P1121Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Hepatocyte growth factor-like protein
    Monoclonal Antibody for Human Hepatocyte growth factor-like protein
    Monoclonal Antibody for Human Hepatocyte growth factor-like protein
    Protein for Human Hepatocyte growth factor-like protein
    Protein for Human Hepatocyte growth factor-like protein
    Protein for Human Hepatocyte growth factor-like protein

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor."
      Han S. , Stuart L.A. , Friezner Degen S.J.
      Biochemistry30:9768-9780(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT TYR-13
      tissue: Liver.
    2. 2.
      "Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3."
      Yoshimura T. , Yuhki N. , Wang M.H. , Skeel A. , Leonard E.J.
      J. Biol. Chem.268:15461-15468(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    3. 3.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity."
      Skeel A. , Yoshimura T. , Showalter S.D. , Tanaka S. , Appella E. , Leonard E.J.
      J. Exp. Med.173:1227-1234(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 230-247; 288-310; 326-341; 484-501; 530-552; 574-596 AND 602-611;SUBUNIT
      tissue: Plasma.
    6. 6.
      "Macrophage stimulating protein (MSP) binds to its receptor via the MSP beta chain."
      Wang M.H. , Julian F.M. , Breathnach R. , Godowski P.J. , Takehara T. , Yoshikawa W. , Hagiya M. , Leonard E.J.
      J. Biol. Chem.272:16999-17004(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MST1R
    7. 7.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-296
      tissue: Plasma.
    8. 8.
      "Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis."
      Goyette P. , Lefebvre C. , Ng A. , Brant S.R. , Cho J.H. , Duerr R.H. , Silverberg M.S. , Taylor K.D. , Latiano A. , Aumais G. , Deslandres C. , Jobin G. , Annese V. , Daly M.J. , Xavier R.J. , Rioux J.D.
      Mucosal Immunol.1:131-138(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN INFLAMMATORY BOWEL DISEASE;VARIANT CYS-689
    9. 9.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-615
      tissue: Liver.
    10. 10.
    11. 11.
      "Proteolytic activation of pro-macrophage-stimulating protein by hepsin."
      Ganesan R. , Kolumam G.A. , Lin S.J. , Xie M.H. , Santell L. , Wu T.D. , Lazarus R.A. , Chaudhuri A. , Kirchhofer D.
      Mol. Cancer Res.9:1175-1186(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC CLEAVAGE
    12. 12.
      "Protein characterization of a candidate mechanism SNP for Crohn's disease: the macrophage stimulating protein R689C substitution."
      Gorlatova N. , Chao K. , Pal L.R. , Araj R.H. , Galkin A. , Turko I. , Moult J. , Herzberg O.
      PLoS ONE6:E27269-E27269(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MST1R;CHARACTERIZATION OF VARIANT CYS-689
    13. 13.
      "Crystal structure of the beta-chain of human hepatocyte growth factor-like/macrophage stimulating protein."
      Carafoli F. , Chirgadze D.Y. , Blundell T.L. , Gherardi E.
      FEBS J.272:5799-5807(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 465-711;INTERCHAIN DISULFIDE BOND
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